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Home  »  Injectable Projects  »  Fermentation Vessels

Fermentation Vessels

Fermentation Vessels manufactured by Neelam industries are the most flexible designed product to meet the requirements of the Pharmaceutical Industry.

Technical Specifications
  • Filling Volume : 65-80%
  • Material : Wetted parts are SS316L, and others is SS304
  • Surface Finish : inside surface is 0.28-0.6µm by electro Poloshoutside surface is 0.4-0.8µm by satin finish.
  • Agitation
    • Fermentor use SEW / Bonfigloli decelerator
    • top mechanical agitator with two layer six blade impeller, one layer defoamer and four baffles.
    • mechanical seal (single or double mechanical seal)
    • speed range: 50-400rpm (it depends on the size of the vessel)
      Or
      Bottom mounted Magnetic mixer with speed variation from 20 to 400 RPM
  • Equips of vessel
    • using alcohol flame inoculation
    • sterilisable sampling and Flush bottom valve
    • CIP & SIP system inbuilt.
    • PH, DO, temp. sensor on lower side, side glass, top with foam and level probe, and 12v sight glass with lamp, etc.
  • Construction : Floor-type One fermentor vessel with one control system

Fermentor Process Chart
Fermentor Process Chart


Main components and controls of system
  • PH :
    • On-line check and measure, and digitization fully automatic control
    • PH, acid and base gang control. Peristatic pump automatically adjust to feed acid and base
    • Control range 2-12pH, measure precision±0.01 pH, control precision±0.1 pH
    • It has auto alarm function
    • pH sensor and signal transmission line, Mettler toledo
  • Do :
    • On-line check and measure, cascade with rpm; digital display.
    • Range 0-100% or 0-200%, precision ±1%;
    • It has auto alarm function
    • DO sensor and signal transmission line, Mettler toledo
  • Foam control :
    • Automatically control and automatically alarm
    • Stainless steel electrode check, peristaltic pump automatically add defoamer.
  • Feed control :
    • Automatically control and automatically alarm
    • Stainless steel electrode check, peristaltic pump automatically feeding
  • Temp. control :
    • PID fully digitization signal processing, digitization control settings
    • Circulating water automatically control temperature
    • Measure range 0-150degree, control range 15- 45degree,control precision±0.2degree
    • Pt 100 O temp. Sensor
    • system with electrical heater to control the temp inside vessel
    • water pump circulation
    • solenoid valve to control
  • Rotate speed :
    • Automatically control , with auto alarm function
    • Siemens frequency converter to adjust the speed
  • Pressure :
    • Manually adjusting with pressure gauge and manual valve (standard system)
    • Automatically adjusting with pressure transmitter and PID valve and pneumatic valves (optional)
  • Air flow :
    • Manually adjusting with rotor meter and manual valve (standard system)
    • Automatically adjusting with mass-flow meter and pneumatic valves (optional)
    • Air in filter , tail gas filter , with PALL cartridge, precision 0.2µm
  • Sterilization :
    • Fermentation vessel can be SIP by connecting with steam
    • Automatic control with pneumatic valves
  • Control : B&R AUSTRIA PLC, and B&R 10.4” touch screen(HMI) and NEELAM INDUSTRIES program


AUTOMATION :

Saturated Steam Steriliser
Saturated Steam Steriliser


In compliance with :
cGMP, GAMP, ISO 9001 : 2008

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Injectable Projects  |  Ointment / Cream Plant   |  Cosmetic Industries  |  Liquid & Oral Projects  |  API Plant  |  Tablet Plant  |  Food & Processing Plant

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