Fermentation Vessels

Fermentation Vessels manufactured by Neelam industries are the most flexible designed product to meet the requirements of the Pharmaceutical Industry.

Technical Specifications

• Filling Volume : 65-80%
• Material : Wetted parts are SS316L, and others is SS304
• Surface Finish : inside surface is 0.28-0.6µm by electro Poloshoutside surface is 0.4-0.8µm by satin finish.
• Agitation
  • Fermentor use SEW / Bonfigloli decelerator
  • top mechanical agitator with two layer six blade impeller, one layer defoamer and four baffles.
  • mechanical seal (single or double mechanical seal)
  • speed range: 50-400rpm (it depends on the size of the vessel)
    Or
    Bottom mounted Magnetic mixer with speed variation from 20 to 400 RPM
• Equips of vessel
  • using alcohol flame inoculation
  • sterilisable sampling and Flush bottom valve
  • CIP & SIP system inbuilt.
  • PH, DO, temp. sensor on lower side, side glass, top with foam and level probe, and 12v sight glass with lamp, etc.
• Construction : Floor-type One fermentor vessel with one control system

Main components and controls of system

• PH :
  • On-line check and measure, and digitization fully automatic control
  • PH, acid and base gang control. Peristatic pump automatically adjust to feed acid and base
  • Control range 2-12pH, measure precision±0.01 pH, control precision±0.1 pH
  • It has auto alarm function
  • pH sensor and signal transmission line, Mettler toledo
• Do :
  • On-line check and measure, cascade with rpm; digital display.
  • Range 0-100% or 0-200%, precision ±1%;
  • It has auto alarm function
  • DO sensor and signal transmission line, Mettler toledo
• Foam control :
  • Automatically control and automatically alarm
  • Stainless steel electrode check, peristaltic pump automatically add defoamer.
• Feed control :
  • Automatically control and automatically alarm
  • Stainless steel electrode check, peristaltic pump automatically feeding
• Temp. control :
  • PID fully digitization signal processing, digitization control settings
  • Circulating water automatically control temperature
  • Measure range 0-150degree, control range 15- 45degree,control precision±0.2degree
  • Pt 100 O temp. Sensor
  • system with electrical heater to control the temp inside vessel
  • water pump circulation
  • solenoid valve to control
• Rotate speed :
  • Automatically control , with auto alarm function
  • Siemens frequency converter to adjust the speed
• Pressure :
  • Manually adjusting with pressure gauge and manual valve (standard system)
  • Automatically adjusting with pressure transmitter and PID valve and pneumatic valves (optional)
• Air flow :
  • Manually adjusting with rotor meter and manual valve (standard system)
  • Automatically adjusting with mass-flow meter and pneumatic valves (optional)
  • Air in filter , tail gas filter , with PALL cartridge, precision 0.2µm
• Sterilization :
  • Fermentation vessel can be SIP by connecting with steam
  • Automatic control with pneumatic valves
• Control : B&R AUSTRIA PLC, and B&R 10.4” touch screen(HMI) and NEELAM INDUSTRIES program

AUTOMATION :

In compliance with :
cGMP, GAMP, ISO 9001 : 2008